HN Hall of Fame Weekly email

Could a Neuroscientist Understand a Microprocessor? (2017)

journals.plos.org Research & data Research papers Medicine & health Candidate
Screenshot of journals.plos.org captured 2026-07-20
Page preview · captured 2026-07-20

Resurfaced independently across 7 calendar years, with breakout response in 2 of them.

submissions
19
submitters
16
observed span
2017–2025
peak thread · 92 comments
249 pts
latest 20+ return · 2019-10-28
146 pts

Submission timeline

2007–2026

One slot for every year since HN launched. Height is that year's peak points; orange marks a 100+ point or 50+ comment breakout. Select a bar to open its strongest thread.

First comments on top threads

HN comment order

Testing analytical methods of a field against engineered artefacts is a good idea but there is a fatal flaw here; devices that do a fetch-decode-execute-retire loop against a register file and a memory bus have perversely little in common with what neurobiology is concerned with. A more appropriate artefact would be a CPU and its memory (where NOP'ing out code or flipping flags corresponds to "lesioning"), or even better, an FPGA design (where different functions work in parallel in different…

zkms·249-point thread·

I wrote a lay summary of this paper that compares and contrasts with the whole brain imaging and stimulation literature for those interested in a lighter read! http://www.neuwritewest.org/blog/can-we-reverse-engineer-the...

tbenst·146-point thread·

Previous discussion: https://news.ycombinator.com/item?id=11780565

See also episode 193 of the podcast "Rationally Speaking." http://rationallyspeakingpodcast.org/show/rs-193-eric-jonas-...

KC8ZKF·4-point thread·

The first top-level comment from each of the four biggest threads, in HN’s own order. Excerpts are shortened; open a comment for full context.

Breakout years
2

100+ points or 50+ comments

Total points
439

reference only — not used in Hall rules or ranking

Total comments
140

reference only — not used in Hall rules or ranking

Every submission